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Anti-α-1-antitrypsin Antibody (13704)

$230.00 – $460.00

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 100ug
1mg
500ug 		ELISA Human
SKU: 13704 Categories: , ,
Overview
Product Name Anti-α-1-antitrypsin Antibody (13704)
Description Anti-α-1-antitrypsin Mouse Monoclonal Antibody
Target α-1-antitrypsin
Species Reactivity Human
Applications ELISA
Host Mouse
Clonality Monoclonal
Clone ID 1AT11-213.5
Isotype IgG1
Immunogen Purified human serum alpha-1-antitrypsin.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by protein G affinity chromatography
Specificity Information
Target Name α-1-antitrypsin
Target ID α-1-antitrypsin
Uniprot ID P01009
Alternative Names α-1 protease inhibitor,α-1-antiproteinase, Serpin A1 [Cleaved into: Short peptide from AAT
Gene Name SERPINA1
Sequence Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.; [Short peptide from AAT]: Secreted, extracellular space, extracellular matrix.
Biological Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
Research Areas Enzymes
Application Images
Additional Information
Handling
Storage These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions These antibodies have been qualified for use in ELISA to detect human a1AT.

End users should determine optimal concentrations for their applications.
References & Data Sheet