Specificity Any #3330 and #3345 epitope group B (ISOBM* classification). #3346 epitope group A (ISOBM* classification)*International Society of Oncology and Biomarkers Human Annexin A1. Reactivity with other species has not been investigated. Human Arginase-1. Reactivity with other species has not been investigated. Human BSEP. Reactivity with other species has not been investigated. Human CD2. Reactivity with other species has not been investigated. Human CD57. Reactivity with other species has not been investigated. Human CDX-2. Reactivity with other species has not been investigated. Human Collagen Type IV. Reactivity with other species has not been investigated. Human Cytokeratin 18. Reactivity with other species has not been investigated. Human Cytokeratin 19. Reactivity with other species has not been investigated. Human E-cadherin. Reactivity with other species has not been investigated. Human Her2/Neu. Reactivity with other species has not been investigated. Human KBA.62. Reactivity with other species has not been investigated. Human Ki-67. Reactivity with other species has not been investigated. Human MLH1. Reactivity with other species has not been investigated. Human MSH2. Reactivity with other species has not been investigated. Human NGFR. Reactivity with other species has not been investigated. Human p53. Reactivity with other species has not been investigated. Human PAX-8. Reactivity with other species has not been investigated. Human PD-1. Reactivity with other species has not been investigated. Human PD-L1. Reactivity with other species has not been investigated. Human PMS2. Reactivity with other species has not been investigated. Human PSA. Reactivity with other species has not been investigated. Human PSAP. Reactivity with other species has not been investigated. Human R132H-IDH1. Reactivity with other species has not been investigated. Human SOX-10. Reactivity with other species has not been investigated. Human TAG-72. Reactivity with other species has not been investigated. Human TIM-3. Reactivity with other species has not been investigated. Mouse and human ROR2. Does not cross-react with ROR1. Recombinant rat PSD95 Recombinant retinoblastoma These antibodies recognize CYFRA21-1. These antibodies recognize different epitopes of human alpha-fetoprotein and do not cross-react with human albumin. These antibodies recognize HE4. The epitope recognized by #34085 is different from the epitope recognized by #34084 and #34086. These antibodies specifically recognize human TS (36 kDa). They do not cross-react with rat TS. This antibody recognizes alpha and b isoforms of human and mouse p53DINP1. This antibody recognizes an 84 kD nuclear matrix protein that was first discovered through its association with the N-terminal region of retinoblastoma protein. This antibody recognizes an epitope at the N-terminus of human, mouse, and rat Chk2 (Checkpoint Kinase 2). In response to DNA damage, ATM phosphorylates and activates Chk2 which in turn directly phos This antibody recognizes an epitope at the N-terminus of human, mouse, and rat p53R2. This antibody recognizes an epitope within aa 223-322 of human E2F-1. This antibody recognizes an epitope within aa 244-264 of human E2F-1. This antibody recognizes an epitope within aa 332-390 of human E2F-1. This antibody recognizes an epitope within the extracellular domain of human TEM5. This antibody recognizes canine PD-1. This antibody recognizes canine PD-L1. This antibody recognizes full-length ATM, a 370 kD nuclear phosphoprotein, which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins ass This antibody recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein, and does not recognize the deltaexon 11 splice variant. In a high proportion of breast and ovarian cancer cell lines, BRCA This antibody recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness This antibody recognizes human AF4. This antibody recognizes human and mouse ch-TOG. A BLAST search demonstrated 100% identity to the peptide immunogen in human, mouse, rat, chimpanzee, dog, cow, chicken, opossum, and frog. This antibody recognizes human and mouse FER1L3. This antibody recognizes human and mouse MLLN. This antibody recognizes human and mouse MTBP which is involved in the p53 network of tumor suppression. p53 transcriptionally activates the MDM2 gene, then the translated MDM2 protein binds to p53 a This antibody recognizes human and mouse PDRG (approx 15 kDa) . This antibody recognizes human and mouse RbAp48 and RbAp46. This antibody recognizes human and mouse RbAp48. This antibody recognizes human and mouse RPA14. RPA (Replication Protein A) is a single-stranded DNA binding protein. Human RPA is a heterotrimeric protein containing subunits of 70, 32, and 14 kD. T This antibody recognizes human and mouse RPA32. RPA (Replication Protein A) is a single-stranded DNA binding protein. Human RPA is a heterotrimeric protein containing subunits of 70, 32, and 14 kD. T This antibody recognizes human and mouse WWOX. Sequence identity to chimpanzee and orangutan WWOX is 100%. This antibody recognizes human and rabbit ER-alpha, a 65 kD protein and a member of the steroid family of nuclear receptors. ER-alpha is a ligand-activated transcription factor that, when bound to es This antibody recognizes human BACH1 protein, a member of the DEAH helicase family. BACH1 interacts with BRCA1, and mutations in BACH1 interfere with normal double-strand DNA break repair. This antibody recognizes human BCAS1/NABC1. This antibody recognizes human cyclin E1, a protein (approx. 50 kD) expressed in elevated levels in human tumor cells. Cyclin E1 controls the initiation of DNA synthesis by activating cdk2, and i exp This antibody recognizes human cyclin E2, a protein (approx. 42 kD) that is elevated in cells that express a papilloma viral oncogene. It interacts with cdk inhibitors of the CIP/KIP family and activ This antibody recognizes human DNA Ligase I (125 kD), one of the four ligase proteins found in mammalian cells that are required for the joining of DNA strand breaks that occur during DNA replication This antibody recognizes human DOG1. This antibody recognizes human EAPII (approx 48 kDa). This antibody recognizes human ENL. This antibody recognizes human ER-b, a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER-b are very similar to ER-alpha with the ligand and DNA binding domain This antibody recognizes human ESE-1 (39-41 kD). This antibody recognizes human FKHR/FOX01. This antibody recognizes human HGAL. This antibody recognizes human hippostatin/KLK11 (35 kDa) which has 86% sequence homology with mouse and rat. This antibody recognizes human KLK3 (prostate specific antigen, PSA), one of the many kallikrein serine proteases associated with carcinogenesis. KLK3 is a specific marker for prostate carcinoma that This antibody recognizes human MCT- 1, a novel gene that was identified in T- cell leukemia/lymphoma cell lines having limited homology to a region of Cyclin H. MCT-1 expression results in a shortene This antibody recognizes human MUC12 (Mucin 12), a novel mucin that appears to be involved in epithelial cell growth regulation. MUC12 is down-regulated in colorectal cancers. This antibody recognizes human NKIAMRE, a novel cyclin-dependent kinase-related protein that appears to play a role in tumor suppression. The NKIAMRE gene is located on chromosome 5q in a region that This antibody recognizes human NKX3.1 (approx. 26 kDa). This sequence is highly conserved in rat and mouse. This antibody recognizes human p53. This antibody recognizes human PERP, a plasma membrane protein involved in the p53 network. p53 binds to the promoter of PERP and transcriptionally activates the PERP gene; the translated PERP protei This antibody recognizes human PRAC protein, a gene product that is expressed in normal human prostate, rectum, and colon as well as in prostate carcinoma. PRAC is localized in cell nuclei and may pl This antibody recognizes human progesterone receptor (PgR), a member of the steroid family of nuclear receptors. PgR is found as a 94 kD protein (Form A) or a 120 kD protein (Form B). Binding of prog This antibody recognizes human prostein (55 kD). This antibody recognizes human PSDR1 (28 kD). This antibody recognizes human RAD17, a novel gene product involved in the DNA damage checkpoint signal transduction pathway. RAD17 plays a central role in cell cycle checkpoint control. This antibody recognizes human Rad50, a 153 kD protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex. Following DNA damage This antibody recognizes human Rad51, a 37 kD protein that interacts with BRCA1. This interaction is important for tumor suppression. BRCA2 and Rad51 have also been shown to interact via the BRC repe This antibody recognizes human Rb protein phosphorylated at serine 249 and threonine 252. Reactivity with other species has not been investigated. This antibody recognizes human Rb protein phosphorylated at serine 612. Reactivity with other species has not been investigated. This antibody recognizes human Rb protein phosphorylated at serine 780. Reactivity with other species has not been investigated. This antibody recognizes human Rb protein phosphorylated at serine 807. Reactivity with other species has not been investigated. This antibody recognizes human Rb protein phosphorylated at serine 811. Reactivity with other species has not been investigated. This antibody recognizes human Rb protein phosphorylated at threonine 821. Reactivity with other species has not been investigated. This antibody recognizes human Rb protein phosphorylated at threonine 826. Reactivity with other species has not been investigated. This antibody recognizes human TERE1. Other species have not been tested. This antibody recognizes human Trip230, a 230 kD protein. The gene for Trip230 is located on chromosome 14q31 in a region associated with genetic alterations and thyroid hormone response abnormalitie This antibody recognizes human XAB2 protein (XPA-binding protein 2) which appears to be involved in transcription- coupled DNA repair and transcription. XAB2 binds to XPA, a key factor in nucleotide This antibody recognizes human, mouse, and chicken DNA Ligase III. Cellular localization is nuclear and mitochondrial. This antibody recognizes human, mouse, and rat BRCAA1. This antibody recognizes human, mouse, and rat Mre11. This antibody recognizes human, mouse, and rat NORE1 (approx 47 kDa). This antibody recognizes human, mouse, and rat PID/MTA2, a subunit of the nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetyl This antibody recognizes human, mouse, rat, and bovine HIF-1alpha. This antibody recognizes human, mouse, rat, hamster, and monkey TSG101 protein. This antibody recognizes mitosin, a 350 kD phosphoprotein that is specifically involved in mitotic-phase progression. Mitosin is expressed throughout S, G2, and M phases of the cell cycle, but is abs This antibody recognizes mouse SHPRH (approx. 185 kDa) which has 90% sequence homology with human and 95% sequence homology with rat. This antibody recognizes native and recombinant human and mouse glypican-1. This antibody recognizes ski protein of human, mouse, rat, chicken, and Xenopus. This antibody recognizes the 95 kD nibrin protein which contains a forkhead-associated domain that is adjacent to BRCT, a breast cancer C- terminal domain involved in protein- protein interactions. p This antibody recognizes the gene product hk12 of human KLK12 (also known as KLK-L5), one of the many kallikrein serine proteases associated with carcinogenesis. KLK12 is expressed in salivary glands This antibody recognizes the gene product hk13 of human KLK13 (also known as KLK-L4), one of the many kallikrein serine proteases associated with carcinogenesis. KLK13 is up- regulated by steroid hor This antibody recognizes the gene product hk14 of human KLK14 (also known as KLK-L6), one of the many kallikrein serine proteases associated with carcinogenesis. KLK14 is expressed in normal and mali This antibody recognizes the gene product hk15 of human KLK15, one of the many kallikrein serine proteases associated with carcinogenesis. KLK15 is associated with more aggressive forms of prostate c This antibody recognizes the gene product hk4 of human KLK4 (also known as KLK-L1), one of the many kallikrein serine proteases associated with carcinogenesis. KLK4 is up- regulated by androgens and This antibody recognizes the gene product hk5 of human KLK5 (also known as KLK-L2), one of the many kallikrein serine proteases associated with carcinogenesis. KLK5 is up- regulated by estrogens and This antibody recognizes the gene product hk9 of human KLK9 (also known as KLK-L3), one of the many kallikrein serine proteases associated with carcinogenesis. KLK9 is expressed in thymus, testis, sp This antibody recognizes the p37 subunit of human and yeast (S. cerevisiae) Replication Factor C (RFC). RFC is a heteropentameric protein consisting of p140, p40, p38, p37, and p36 subunits, RFC part This antibody specifically recognizes human thymidine kinase.
