Anti-BACH1 Antibody (56246)

$376.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

SKU: 56246 Categories: Antibody Products, Cancer Research Antibodies, Products

Overview

Product Name Anti-BACH1 Antibody (56246)

Description Anti-BACH1 Rabbit Polyclonal Antibody

Target BACH1

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Peptide corresponding to aa 1233-1249 of the human BACH1 protein.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by immunoaffinity chromatography

Specificity This antibody recognizes human BACH1 protein, a member of the DEAH helicase family. BACH1 interacts with BRCA1, and mutations in BACH1 interfere with normal double-strand DNA break repair.

Target Name Transcription regulator protein BACH1

Target ID BACH1

Uniprot ID O14867

Alternative Names BTB and CNC homolog 1, HA2303

Gene Name BACH1

Sequence Location Nucleus

Biological Function Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {UniProtKB:P97302, PubMed:24035498}.

Research Areas Cancer research

Handling

Storage This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze- thaw cycles.

Dilution Instructions Dilute in PBS or medium which is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. A band of approximately 81 kD is detected.

Data Sheet