Fibroblast Growth Factor-acidic (45101)

$341.00

Note: This product has a $35.00 Dry Ice Fee.

Host	Quantity	Applications	Species Reactivity	Data Sheet
	20ug	WB,ELISA	Human

SKU: 45101 Categories: Products, Recombinant Proteins Tag: Dry Ice

Overview

Product Name Fibroblast Growth Factor-acidic (45101)

Description Recombinant Human Acidic Fibroblast Growth Factor

Target Fibroblast Growth Factor-acidic

Species Reactivity Human

Applications WB,ELISA

Source Genetically-engineered E. coli

Properties

Form Liquid

Concentration Lot Specific

Formulation 0.1% trifluoroacetic acid + 40% acetonitrile.

Molecular Mass Molecular Weight: 15,000 Da

Purity >90%

Background Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1

Target Name Fibroblast Growth Factor-acidic

Target ID Fibroblast Growth Factor-acidic

Alternative Names rHuFGFa

Biological Activity Fibroblast Growth Factor-acidic

Handling

Storage This product is stable for at least one (1) year at -20°C to -70°C. Keep frozen until use. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

References Burgess, WH and Maciag, T (1989) Annual Rev Boichem 58: 575.

Data Sheet