Anti-Interleukin-22 Receptor (IL-22R) (NT) Antibody (40107)

$445.00

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug ELISA,WB,IHC-P,ICC,IF Human
SKU: 40107 Categories: , ,
Overview
Product Name Anti-Interleukin-22 Receptor (IL-22R) (NT) Antibody (40107)
Description Anti-IL-22R (NT) Rabbit Polyclonal Antibody
Target Interleukin-22 Receptor (IL-22R) (NT)
Species Reactivity Human
Applications ELISA,WB,IHC-P,ICC,IF
Host Rabbit
Clonality Polyclonal
Immunogen Peptide corresponding to aa 31-46 of human IL-22R precursor.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes an epitope at the N-terminus of human IL-22R, the receptor for IL-22. IL-22R complexes with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate the JAK-STAT signaling pathway. IL-22R is expressed in normal liver and kidney and in the cell lines HepG2 and TK-10.
Target Name Interleukin-22 receptor subunitα-1
Target ID Interleukin-22 Receptor (IL-22R) (NT)
Uniprot ID Q8N6P7
Alternative Names IL-22 receptor subunitα-1, IL-22R-α-1, IL-22RA1, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, CRF2-9, ZcytoR11
Gene Name IL22RA1
Sequence Location Membrane; Single-pass type I membrane protein.
Biological Function Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {PubMed:11035029, PubMed:11564763, PubMed:11706020, PubMed:12351624, PubMed:12941841, PubMed:17204547}.
Research Areas Growth Factors, Cytokines, Receptors
Application Images
Description Western blot analysis of IL-22 receptor expression in human HepG2 cell lysate with IL-22 receptor antibody at (A) 0.5 and (B) 1 ug/ml.
Description Immunohistochemistry of IL-22R in rat kidney tissue with IL-22R antibody at 5 ug/mL.
Description Immunofluorescence of IL-22 receptor in HepG2 cells with IL-22 receptor antibody at 10 ug/mL.
Description Immunocytochemistry of IL-22 receptor in HepG2 cells with IL-22 receptor antibody at 10 ug/mL.
Description Immunofluorescence of IL-22R in rat kidney tissue with IL-22R antibody at 20 ug/ml.
Additional Information
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 62 kD is detected.

Positive control: HepG2 cell lysate.
References & Data Sheet