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Interleukin-1 Receptor Antagonist (40101P-20)

$181.00

Host Quantity Applications Species Reactivity Data Sheet  
20ug WB Human
SKU: 40101P-20 Categories: ,
Overview
Product Name Interleukin-1 Receptor Antagonist (40101P-20)
Description Recombinant human IL-1RA produced in E. coli is a non-glycosylated N- terminal methionyl form of the naturally- occurring polypeptide containing 153 amino acids with a molecular weight of 17kDa.
Target Interleukin-1 Receptor Antagonist
Species Reactivity Human
Applications WB
Source Escherichia coli
Properties
Form Lyophilized
Purity Greater than 98% as determined by SDS-PAGE and RP- HPLC
Background Interleukin-1RA is a member of the Interleukin-1 (IL-1) cytokine family. It inhibits the activities of of IL-1 alpha and IL-1 beta and modulates a variety of IL- 1-related immune and inflammatory responses. A polymorphism of this gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer.
Specificity Information
Target Name Interleukin-1 receptor antagonist protein
Target ID Interleukin-1 Receptor Antagonist
Alternative Names rHuIL-1RA
Sequence Location [Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm.
Sequence The sequence of the first five N-terminal amino acids is Met-Arg-Pro-Ser-Gly.
Biological Activity Interleukin-1 Receptor Antagonist
Biological Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than dPubMed:7775431}.
Background Interleukin-1RA is a member of the Interleukin-1 (IL-1) cytokine family. It inhibits the activities of of IL-1 alpha and IL-1 beta and modulates a variety of IL- 1-related immune and inflammatory responses. A polymorphism of this gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer.
Application Images
Additional Information
Handling
Storage Store dessicated below -18°C. After reconstitution, store at 4°C for 2-7 days and below -18°C for future use. For long term storage of the reconstituted product, addition of 0.1% human serum albumin or bovine serum albumin is recommended. Avoid multiple freeze- thaw cycles.
Dilution Instructions Reconstitute in sterile distilled H2O to not less than 100ug/ml which can be further diluted in other aqueous solutions.
References & Data Sheet