Anti-TERE1 Antibody (34031)
$278.00
| Host | Quantity | Applications | Species Reactivity | Data Sheet | |
|---|---|---|---|---|---|
| Rabbit | 100ug | WB | Human |  |
Overview
Product Name Anti-TERE1 Antibody (34031)
Description Anti-TERE1 Rabbit Polyclonal Antibody
Target TERE1
Species Reactivity Human
Applications WB
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids 32-45 of human TERE1. This sequence is 85
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by Protein G affinity chromatography
Specificity Information
Specificity This antibody recognizes human TERE1. Other species have not been tested.
Target Name UbiA prenyltransferase domain-containing protein 1
Target ID TERE1
Uniprot ID Q9Y5Z9
Alternative Names EC 2.5.1.-, Transitional epithelial response protein 1
Gene Name UBIAD1
Sequence Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane. Cytoplasm. Nucleus.
Biological Function Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. {PubMed:20953171, PubMed:23374346}.
Research Areas Cancer research
Background A ubiquitously expressed gene designated TERE1 (Transitional Epithelial Response Gene 1), which maps to chromosome 1p36.11-1p36.33, has a significant effect on growth regulation of bladder cancer and may play an equally significant role in growth regulation of prostate cancer. The TERE1 gene is located between the micro- satellite markers D1S2667 and D1S434, a chromosome locus that has been identified as a site of a tumor suppressor gene or genes for multiple tumor types. Induced TERE1 expression in two prostate carcinoma cell lines, LNCaP and PC-3, decreased proliferation up to 80% with a significant increase in the number of cells in G1. The TERE1 transcript is present in most normal human tissues, but is reduced or absent in the majority of muscle invasive TCC (Transitional Cell Carcinoma of the bladder) tumors.
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting : use at 1-5ug/ml. A band of approximately 37 kDa is detected.
These are recommended concentrations. User should determine optimal concentrations for their applications.
These are recommended concentrations. User should determine optimal concentrations for their applications.
References & Data Sheet
Data Sheet 
Download PDF Data Sheet
Download PDF Data Sheet