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Anti-Streptococcus pneumoniae Type 5 Polysaccharide Antibody (22006)

$400.00

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 100ug ELISA Streptococcus Pneumoniae Type 5 Polysaccharide
SKU: 22006 Categories: , ,
Overview
Product Name Anti-Streptococcus pneumoniae Type 5 Polysaccharide Antibody (22006)
Description Anti-Streptococcus pneumoniae Type 5 Polysaccharide Mouse Monoclonal Antibody
Target Streptococcus pneumoniae Type 5 Polysaccharide
Species Reactivity Streptococcus Pneumoniae Type 5 Polysaccharide
Applications ELISA
Host Mouse
Clonality Monoclonal
Clone ID 5F6
Isotype IgG3
Immunogen Streptococcus pneumoniae 5 cells.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification PEG Purified
Specificity Information
Specificity This antibody recognizes pneumococcal type 5 polysaccharide. It does not cross- react with s 14 or 23F.
Target ID Streptococcus pneumoniae Type 5 Polysaccharide
Research Areas Infectious Disease
Background Streptococcus pneumoniae are Gram-positive bacteria normally found in the upper respiratory tract including the throat and nasal passages. Streptococcus pneumoniae is characterized by a polysaccharide capsule that completely encloses the cell and plays a key role in its virulence. The cell wall of S. pneumoniae is composed of peptidoglycan with teichoic acid attached to every third N-acetylmuramic acid. Lipoteichoic acid is attached via a lipid moiety, and both teichoic and lipoteichoic acid contain phosphorylcholine. Two choline residues may exist on each carbohydrate repeat, which is important to S. pneumoniae because the choline adheres to choline-binding receptors located on human cells.
Application Images
Additional Information
Handling
Storage These antibodies are stable for at least one (1) year from date of receipt at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions ELISA: qualified for reactivity with Strep. pneumoniae 5 cells and with purified type 5 pneumococcal polysaccharides (ATCC nos. 37-X and 57-X).Not all applications have been investigated.

End users should determine optimal concentrations for their applications.
References & Data Sheet
References McDaniel L. et al. 1984 Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae. J Exp Med 160: 386-397.McDaniel L. et al. 1987 A protective monoclonal antibody that reacts with a novel antigen of pneumococcal teichoic acid. Microbial Pathogenesis 3: 249-260.Crain MJ et al. 1990 Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular s of Streptococcus pneumoniae. Infection and Immunity 58: 3293-3299.McDaniel L. et al. 1991 PspA, A surface protein of Streptococcus pneumoniae, is capable of eliciting protection against Pneumococci of more than one capsular type. Infection and Immunity 59: 222-228.