Anti-Glycogen Phosphorylase, brain, Antibody (13806)

$454.00

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 50ug IHC,IHC-P Human
SKU: 13806 Categories: , ,
Overview
Product Name Anti-Glycogen Phosphorylase, brain, Antibody (13806)
Description Anti-Glycogen Phosphorylase, brain Rabbit Polyclonal Antibody
Species Reactivity Human
Applications IHC,IHC-P
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide conjugated to KLH.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS containing 0.1% sodium azide
Buffer Formulation Phosphate Buffered Saline
Buffer Anti-Microbial 0.1% Sodium Azide
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes an internal domain of human brain GP.
Target Name Glycogen phosphorylase, brain form
Uniprot ID P11216
Alternative Names EC 2.4.1.1
Gene Name PYGB
Accession Number NP_002853.2
Biological Function Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228). {PubMed:27402852, PubMed:3346228}.
Research Areas Enzymes
Background Glycogen phosphorylase (GP) removes and converts one glucose molecule from glycogen to glucose-1-phosphate. Mammalian GPs are found in at least three isozymic forms that are distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed. The brain isozyme of GP is associated primarily with providing an emergency glucose supply during periods of anoxia or hypoglycemia. A549 non-small cell lung carcinoma cells express solely the brain isozyme of GP and have been used to investigate inhibitors of GP that retard cell growth.
Application Images
Description Immunohistochemistry: Use at 10ug/ml. Brain: Formalin-fixed, paraffin-embedded
Additional Information
Handling
Storage This antibody is stable at 4°C (short- term) and -70°C (long-term).
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions

Immunohistochemistry: Use at 10ug/ml.
References & Data Sheet