Anti-Tumor Endothelial Marker 5 Antibody (34028)

$454.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	50ug	IHC,IHC-P	Human

SKU: 34028 Categories: Antibody Products, Cancer Research Antibodies, Products

Overview

Product Name Anti-Tumor Endothelial Marker 5 Antibody (34028)

Description Anti-Tumor Endothelial Marker 5 Rabbit Polyclonal Antibody

Target Tumor Endothelial Marker 5

Species Reactivity Human

Applications IHC,IHC-P

Host Rabbit

Clonality Polyclonal

Immunogen Synthetic peptide conjugated to KLH

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS containing 0.1% sodium azide

Buffer Formulation Phosphate Buffered Saline

Buffer Anti-Microbial 0.1% Sodium Azide

Format Purified

Purification Purified by immunogen affinity chromatography

Specificity This antibody recognizes an epitope within the extracellular domain of human TEM5.

Target Name Tumor endothelial marker 5

Target ID Tumor Endothelial Marker 5

Uniprot ID Q6YN44

Gene Name TEM5

Research Areas Cancer research

Background Tumor endothelial marker 5 (TEM5) is a member of the adhesion family of GPCRs and is upregulated in endothelial cells during tumor and physiologic angiogenesis. Soluble TEM5 (sTEM5) is shed by endothelial cells during angiogenesis and binds to glycosaminoglycans on extracellular matrix and cell surface proteoglycans. After proteolytic processing, an RGD- binding site for integrin alphavbeta3 is exposed on sTEM5. Adhesion of endothelial cells to immobilized proteolytically processed sTEM5 promotes their survival.