Anti-PSDR1 Antibody (34007)
$376.00
SKU: 34007
Categories: Antibody Products, Cancer Research Antibodies, Products
Overview
Product Name Anti-PSDR1 Antibody (34007)
Description Anti-PSDR1 Rabbit Polyclonal Antibody
Target PSDR1
Species Reactivity Human
Applications WB,ELISA
Host Rabbit
Clonality Polyclonal
Immunogen N-terminal sequence MVELMFP and C-terminal sequence LLGLPID of human PSDR1.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS.
Buffer Formulation Phosphate Buffered Saline
Format Purified
Purification Purified by immunoaffinity chromatography
Specificity Information
Specificity This antibody recognizes human PSDR1 (28 kD).
Target Name Retinol dehydrogenase 11
Target ID PSDR1
Uniprot ID Q8TC12
Alternative Names EC 1.1.1.300, Androgen-regulated short-chain dehydrogenase/reductase 1, HCV core-binding protein HCBP12, Prostate short-chain dehydrogenase/reductase 1, Retinal reductase 1, RalR1, Short chain dehydrogenase/reductase family 7C member 1
Gene Name RDH11
Sequence Location Endoplasmic reticulum membrane, Single-pass type II membrane protein
Biological Function Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956). {PubMed:12036956, PubMed:12226107, PubMed:15865448, PubMed:29410696}.
Research Areas Cancer research
Background Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate cancer. PSDR1 (prostate short-chain dehydrogenase- reductase 1) is a novel gene whose expression is increased following exposure of LNCaP cells to androgens. PSDR1 is highly expressed in the human prostate gland and is localized in both normal and neoplastic prostate epithelium. It has been suggested that PSDR1 may play a role in the pathogenesis of prostate cancer.
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution
ELISA: use at 1:1,000-1:5,000 dilution.
ELISA: use at 1:1,000-1:5,000 dilution.
References & Data Sheet
Data Sheet Download PDF Data Sheet