Anti-PDRG Antibody (34012)
$400.00
| Host | Quantity | Applications | Species Reactivity | Data Sheet | |
|---|---|---|---|---|---|
| Rabbit | 100ug | WB,ELISA | Human |  |
Overview
Product Name Anti-PDRG Antibody (34012)
Description Anti-PDRG Rabbit Polyclonal Antibody
Target PDRG
Species Reactivity Human
Applications WB,ELISA
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to the aa sequence CDHLDKEIEKLRKQLK of human PDRG conjugated to KLH.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes human and mouse PDRG (approx 15 kDa) .
Target Name p53 and DNA damage-regulated protein 1
Target ID PDRG
Uniprot ID Q9NUG6
Gene Name PDRG1
Sequence Location Cytoplasm
Biological Function May play a role in chaperone-mediated protein folding. {ECO:0000305}.
Research Areas Cancer research
Background PDRG (p53 and DNA damage-regulated gene) is predominantly expressed in normal human testis but can be detected at lower levels in other organs. PDRG mRNA is upregulated after exposure of cells to UV radiation but is downregulated by tumor suppressor p53. Sequence analysis of PDRG promoter revealed the presence of an Oct-1 binding site as well as a p53 binding site. PDRG is a novel gene in that it is differentially regulated by p53 and UV radiation.
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting : use at 1:500-1:1,000 dilution.
Positive control: Normal human or mouse testis.
Positive control: Normal human or mouse testis.
Download PDF Data Sheet