Anti-MCT-1 Antibody (56228)

$376.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

SKU: 56228 Categories: Antibody Products, Cancer Research Antibodies, Products

Overview

Product Name Anti-MCT-1 Antibody (56228)

Description Anti-MCT-1 Rabbit Polyclonal Antibody

Target MCT-1

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Peptide corresponding to aa 3-14 of human MCT-1 protein.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by peptide immuno-affinity chromatography

Specificity This antibody recognizes human MCT- 1, a novel gene that was identified in T- cell leukemia/lymphoma cell lines having limited homology to a region of Cyclin H. MCT-1 expression results in a shortened G1 phase and increased rate of proliferation.

Target Name Monocarboxylate transporter 1

Target ID MCT-1

Uniprot ID P53985

Alternative Names MCT 1, Solute carrier family 16 member 1

Gene Name SLC16A1

Sequence Location Cell membrane, Multi-pass membrane protein

Biological Function Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. {PubMed:17701893}.

Research Areas Cancer research

Handling

Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Dilution Instructions Dilute in PBS or medium which is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. A band at approx. 20 kD is detected.

Data Sheet