Anti-KLK14 Antibody (56242)

$376.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

SKU: 56242 Categories: Antibody Products, Cancer Research Antibodies, Products

Overview

Product Name Anti-KLK14 Antibody (56242)

Description Anti-KLK14 Rabbit Polyclonal Antibody

Target KLK14

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Peptide corresponding to aa 239-251 of human KLK14 protein.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by immunoaffinity chromatography

Specificity This antibody recognizes the gene product hk14 of human KLK14 (also known as KLK-L6), one of the many kallikrein serine proteases associated with carcinogenesis. KLK14 is expressed in normal and malignant glandular epithelial cells.

Target Name Kallikrein-14

Target ID KLK14

Uniprot ID Q9P0G3

Alternative Names hK14, EC 3.4.21.-, Kallikrein-like protein 6, KLK-L6

Gene Name KLK14

Sequence Location Secreted, extracellular space

Biological Function Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. {PubMed:15654974, PubMed:16885167, PubMed:17158887, PubMed:17625593, PubMed:18056261, PubMed:18482984}.

Research Areas Cancer research

Handling

Storage This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze-thaw cycles.

Dilution Instructions Dilute in PBS or medium which is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. A band of approximately 31 kD is detected.

Data Sheet