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Anti-GRIM-19 Antibody (11010)

$362.00

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug ELISA Human
SKU: 11010 Categories: , ,
Overview
Product Name Anti-GRIM-19 Antibody (11010)
Description Anti-GRIM-19 Rabbit Polyclonal Antibody
Target GRIM-19
Species Reactivity Human
Applications ELISA
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant human GRIM-19 protein.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes human GRIM-19 (Genes associated with Retinoid-IFN- induced Mortality), a nuclear protein that functions as a cell death regulatory molecule. Antisense expression of GRIM-19 confers a strong resistance to IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA.
Target Name NADH dehydrogenase [ubiquinone] 1α subcomplex subunit 13
Target ID GRIM-19
Uniprot ID Q9P0J0
Alternative Names Cell death regulatory protein GRIM-19, Complex I-B16.6, CI-B16.6, Gene associated with retinoic and interferon-induced mortality 19 protein, GRIM-19, Gene associated with retinoic and IFN-induced mortality 19 protein, NADH-ubiquinone oxidoreductase B16.6 subunit
Gene Name NDUFA13
Gene ID 51079
Accession Number NP_057049
Sequence Location Mitochondrion inner membrane
Biological Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). {PubMed:12628925, PubMed:12867595, PubMed:15753091, PubMed:27626371}.
Research Areas Apoptosis
Application Images
Additional Information
Handling
Storage Store at 2 - 8°C until expiration on packaging.
Dilution Instructions Dilute in PBS or medium which is identical to that used in the assay system.
Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. A band of approx. 16kDa is detected.

Positive control: HeLa cell lysate.

These are recommended concentrations.

End user should determine optimal concentrations for their applications.
References & Data Sheet