Anti-FK-506 Antibody (17301)

$340.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Mouse	250ug	ELISA,WB	Fk-506

SKU: 17301 Categories: Antibody Products, Drug Antibodies, Products

Overview

Product Name Anti-FK-506 Antibody (17301)

Description Anti-FK-506 Mouse Monoclonal Antibody

Target FK-506

Species Reactivity Fk-506

Applications ELISA,WB

Host Mouse

Clonality Monoclonal

Clone ID FK1

Isotype IgM

Immunogen FK-506 conjugated to bovine serum albumin.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS containing 0.1% sodium azide

Buffer Formulation Phosphate Buffered Saline

Buffer Anti-Microbial 0.1% Sodium Azide

Format Purified

Purification Purified by immunoaffinity chromatography

Specificity This antibody recognizes conjugated and non-conjugated FK-506 (Kd=10-9 M).

Target ID FK-506

Research Areas Drugs

Background FK-506 is a novel macrolide with similar, but more potent, immunosuppressant activity than cyclosporine. FK-506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant side effects of FK-506 administration are nephrotoxicity, neurotoxicity, diabetes mellitus, and hypertension. Most of these side effects are related to blood levels of FK-506 rather than dosage. Therefore, therapeutic drug monitoring of FK-506 is a prerequisite for therapy. The whole blood target level range aimed for in clinical practice is 3.0-20.0 ng/ml and depends on the patient's liver function, the nature of organ transplantation, and the time after transplantation.

Handling

Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

Application Instructions This antibody may be used in ELISA and Western blotting to detect FK-506.

Data Sheet