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Anti-Factor XII Light Chain Antibody (19802)

$538.00

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 250ug ELISA,Coagulation Assays Human
SKU: 19802 Categories: , , ,
Overview
Product Name Anti-Factor XII Light Chain Antibody (19802)
Description Anti-Factor XII Light Chain Mouse Monoclonal Antibody
Target Factor XII Light Chain
Species Reactivity Human
Applications ELISA,Coagulation Assays
Host Mouse
Clonality Monoclonal
Clone ID C6B7
Isotype IgG1
Immunogen Purified human Factor XII.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by Protein G affinity chromatography
Specificity Information
Specificity Purified human Factor XII.
Target Name Coagulation factor XII
Target ID Factor XII Light Chain
Uniprot ID P00748
Alternative Names EC 3.4.21.38, Hageman factor, HAF [Cleaved into: Coagulation factor XIIa heavy chain; β-factor XIIa part 1; Coagulation factor XIIa light chain
Gene Name F12
Sequence Location Secreted.
Biological Function Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. {PubMed:21304106}.
Research Areas Coagulation factors.
Application Images
Additional Information
Handling
Storage These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions This antibody may be used in ELISA to detect/quantitate Factor XII and in coagulation assays. Other applications are under investigation.
References & Data Sheet