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Anti-Clostridium tetani Toxin Antibody (18918)

$691.00

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 1mg Clostridium Tetani Toxin
SKU: 18918 Categories: , ,
Overview
Product Name Anti-Clostridium tetani Toxin Antibody (18918)
Description Anti-Clostridium tetani Toxin Mouse Monoclonal Antibody
Target Clostridium tetani Toxin
Species Reactivity Clostridium Tetani Toxin
Host Mouse
Clonality Monoclonal
Clone ID B417M
Isotype IgG1
Immunogen Toxin purified from culture filtrate of C. tetani.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by immunoaffinity chromatography
Specificity Information
Specificity This antibody recognizes C. tetani toxin.
Target Name Tetanus toxin
Target ID Clostridium tetani Toxin
Uniprot ID P04958
Gene Name tetX
Biological Function Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
Research Areas Infectious Disease
Background Clostridium tetani is an anaerobic, gram-positive, spore-forming rod found in soil and in the intestinal tracts and feces of animals. Most cases of tetanus result C. tetani spores entering small puncture wound. Infections remain localized, but systemic damage results from the production of exotoxins that are released when the spores germinate and grow. Tetanus toxin “Tetanospasmin†is one of the most potent toxins known, third only to botulinum toxin and diphtheria toxin. This potent neurotoxin enters peripheral nerves and travels to the central nervous system where it interferes with the release of neurotransmitters, causing muscle contraction and spasm.
Application Images
Additional Information
Handling
Storage This antibody is stable for at least one (1) year at -20° to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions ELISAImmunoblotting A band of ~150,000 is detected.

End users should determine optimal dilutions for their applications.
References & Data Sheet