Anti-Chemoattractant Receptor Homologus molecule (CRTH2) Antibody (41013)

$376.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

SKU: 41013 Categories: Antibody Products, Growth Factors/Cytokines/Receptor Antibodies, Products

Overview

Product Name Anti-Chemoattractant Receptor Homologus molecule (CRTH2) Antibody (41013)

Description Anti-CRTH2 Rabbit Polyclonal Antibody

Target Chemoattractant Receptor Homologus molecule (CRTH2)

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Human CRTH2 protein.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by immunoaffinity chromatography

Specificity This antibody recognizes human CRTH2 (Chemoattractant Receptor Homologous molecule), a member of the G protein-coupled leukocyte chemoattractant receptor family. CRTH2 is expressed by Th2, but not Th1 cells, in response to activators such as allergens.

Target Name Prostaglandin D2 receptor 2

Target ID Chemoattractant Receptor Homologus molecule (CRTH2)

Uniprot ID Q9Y5Y4

Alternative Names Chemoattractant receptor-homologous molecule expressed on Th2 cells, G-protein coupled receptor 44, CD antigen CD294

Gene Name PTGDR2

Sequence Location Cell membrane

Biological Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {PubMed:11208866, PubMed:11535533, PubMed:17196174}.

Research Areas Growth Factors, Cytokines, Receptors

Handling

Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. In immunoblots, a band of approximately 55-70 kD is detected.

Data Sheet